Bevacizumab induced a correlation between Tie2 and the tumor vascular imaging biomarker, K<sup>trans</sup> (R:-0.21 to 0.47) implying that Tie2 originated from the tumor vasculature.
We generated K1735 murine melanoma tumor cells that inducibly express soluble Tie2 receptor (Tie2Ex) to study the effects of inhibiting Tie2 signaling on tumor vasculature.